OMRF receives $2.25 million grant to study vision loss

Posted on 02/27/2018

Oklahoma Medical Research Foundation scientist Scott Plafker, Ph.D., has received a four-year grant from the National Institutes of Health to study whether a natural compound can help prevent a common eye disease.
The grant, awarded by the National Eye Institute, will provide Plafker with $2.25 million to investigate whether sulforaphane, which is found naturally in broccoli, cabbage, cauliflower and Brussels sprouts, can protect against age-related macular degeneration.
The compound has previously been shown to protect cells from stress and to have anti-cancer effects.  
“The positive effects of sulforaphane are so widespread that it is in about 30 clinical trials at this very moment covering a variety of diseases ranging from schizophrenia to emphysema to autism,” said Plafker, a scientist in OMRF’s Aging and Metabolism Research Program. “With this grant, we are going to look at its protective effects specifically in age-related macular degeneration.”
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness among the elderly in the U.S. This complex disease is characterized by death of the light-sensing photoreceptors cells in the macula region near the center of the retina. As a consequence, patients progressively lose their central vision.
With the new grant, Plafker and his OMRF research team will seek to determine if sulforaphane can preserve vision by maintaining and protecting the layer of cells in the retina that supports the function of light-sensing photoreceptors.
“I am excited about this because this is readily available in vegetables for cheap,” said Plafker. “People can get this with ease without prescriptions or high costs. That’s the best kind of treatment.”
Plafker’s research will be done in collaboration with Michael Boulton, Ph.D., from the University of Alabama at Birmingham School of Medicine and Raju Rajala, Ph.D., from the Dean McGee Eye Institute.
The grant, 1 R01 024944-01A1, is funded through the NEI, a part of the National Institutes of Health.

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